Article
Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2010
Thomson Glenys, Marthandan Nishanth, Hollenbach Jill A, Mack Steven J, Erlich Henry A, Single Richard M, Waller Matthew J, Marsh Steven G E, Guidry Paula A, Karp David R, Scheuermann Richard H, Thompson Susan D, Glass David N, Helmberg Wolfgang
Abstract excerpt
The immune response HLA class II DRB1 gene provides the major genetic contribution to Juvenile Idiopathic Arthritis (JIA), with a hierarchy of predisposing through intermediate to protective effects. With JIA, and the many other HLA associated diseases, it is difficult to identify the combinations of biologically relevant amino acid (AA) residues directly involved in disease due to the high level of HLA...
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