Article
HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2015
Ombrello Michael J, Remmers Elaine F, Tachmazidou Ioanna, Grom Alexei, Foell Dirk, Haas Johannes-Peter, Martini Alberto, Gattorno Marco, Özen Seza, Prahalad Sampath, Zeft Andrew S, Bohnsack John F, Mellins Elizabeth D, Ilowite Norman T, Russo Ricardo, Len Claudio, Hilario Maria Odete E, Oliveira Sheila, Yeung Rae S M, Rosenberg Alan, Wedderburn Lucy R, Anton Jordi, Schwarz Tobias, Hinks Anne, Bilginer Yelda, Park Jane, Cobb Joanna, Satorius Colleen L, Han Buhm, Baskin Elizabeth, Signa Sara, Duerr Richard H, Achkar J P, Kamboh M Ilyas, Kaufman Kenneth M, Kottyan Leah C, Pinto Dalila, Scherer Stephen W, Alarcón-Riquelme Marta E, Docampo Elisa, Estivill Xavier, Gül Ahmet, de Bakker Paul I W, Raychaudhuri Soumya, Langefeld Carl D, Thompson Susan, Zeggini Eleftheria, Thomson Wendy, Kastner Daniel L, Woo Patricia
Abstract excerpt
Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening childhood inflammatory disease, the pathophysiology of which is poorly understood. To determine whether genetic variation within the MHC locus on chromosome 6 influences sJIA susceptibility, we performed an association study of 982 children with sJIA and 8,010 healthy control subjects from nine countries. Using...
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