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Article

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.

Development (Cambridge, England) - 1 Jan 2009

Yu Jing, Carroll Thomas J, Rajagopal Jay, Kobayashi Akio, Ren Qun, McMahon Andrew P

Abstract excerpt

The mammalian kidney is organized into a cortex where primary filtration occurs, and a medullary region composed of elongated tubular epithelia where urine is concentrated. We show that the cortico-medullary axis of kidney organization and function is regulated by Wnt7b signaling. The future collecting duct network specifically expresses Wnt7b. In the absence of Wnt7b, cortical epithelial development is normal...

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Identifiers

PMID: 19060336
DOI: 10.1242/dev.022087
PMCID: PMC2685965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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