Article

Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis

2023-04-06

Abstract excerpt

<h4>Summary</h4> Defective centrosome function can disrupt embryonic kidney development, by causing changes to the renal interstitium that leads to fibrocystic disease pathologies. Yet, it remains unknown how mutations in centrosome genes impact kidney interstitial cells. Here, we examined the consequences of defective centrosome biogenesis on stromal progenitor cell growth, differentiation and fate. Conditional...

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Literature Corpus work: 64aa9178-8d77-56ba-bc41-c846a9683fb4
DOI: 10.1101/2023.04.04.535583

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