Article
The role of Asp116 in the reductive cleavage of dioxygen to water in CotA laccase: assistance during the proton-transfer mechanism.
Acta crystallographica. Section D, Biological crystallography - 1 Feb 2012
Silva Catarina S, Damas João M, Chen Zhenjia, Brissos Vânia, Martins Lígia O, Soares Cláudio M, Lindley Peter F, Bento Isabel
Abstract excerpt
Multi-copper oxidases constitute a family of proteins that are capable of coupling the one-electron oxidation of four substrate equivalents to the four-electron reduction of dioxygen to two molecules of water. The main catalytic stages occurring during the process have already been identified, but several questions remain, including the nature of the protonation events that take place during the reductive...
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