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Article

The catalytic properties of Thermus thermophilus SG0.5JP17-16 laccase were regulated by the conformational dynamics of pocket loop 6.

Biochimica et biophysica acta. General subjects - 1 Jun 2021

Zhang Yi, Dai Zhuojun, Zhang Shumin, Yang Xiaorong

Abstract excerpt

BACKGROUND: Laccase is one member of the blue multicopper oxidase family. It can catalyze the oxidation of various substrates. The Thermus thermophilus SG0.5JP17-16 laccase (lacTT) is thermostable, pH-stable, and high tolerance to halides, and can decolorize the synthetic dyes. In lacTT, the function of the loop 6 constructing the substrate-binding pocket wasn't clear. METHODS: The residues Asp394 and Asp396...

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Identifiers

PMID: 33588000
DOI: 10.1016/j.bbagen.2021.129872

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