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Article

The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine.

Biochemistry - 2 May 2017

Machuqueiro Miguel, Victor Bruno, Switala Jacek, Villanueva Jacylyn, Rovira Carme, Fita Ignacio, Loewen Peter C

Abstract excerpt

The unusual Met-Tyr-Trp adduct composed of cross-linked side chains along with an associated mobile Arg is essential for catalase activity in catalase-peroxidases. In addition, acidic residues in the entrance channel, in particular an Asp and a Glu ∼7 and ∼15 Å, respectively, from the heme, significantly enhance catalase activity. The mechanism by which these channel carboxylates influence catalase activity is...

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Identifiers

PMID: 28409923
DOI: 10.1021/acs.biochem.6b01276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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