Amino acids located in the outer-sphere of the trinuclear copper center in a multicopper oxidase, CueO as the putative electron donor in the four-electron reduction of dioxygen.

Abstract excerpt

The reaction mechanism of multicopper oxidase (MCO) to reduce dioxygen to water has not been fully understood yet in spite of extensive studies including on the intermediate I (peroxide intermediate) and intermediate II (native intermediate with an O-centered structure at the trinuclear copper center (TNC)). We performed the Phe mutations at the four amino acids, Tyr69, Cys138, Trp139, and Tyr496 located in the...

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