Role of conserved arginine in the heme distal site of HutZ from Vibrio cholerae in the heme degradation reaction.

doi:10.1016/j.abb.2019.108165

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Article

Role of conserved arginine in the heme distal site of HutZ from Vibrio cholerae in the heme degradation reaction.

Archives of biochemistry and biophysics - 30 Nov 2019

Uchida Takeshi, Dojun Nobuhiko, Ota Kazuki, Sekine Yukari, Nakamura Yuina, Umetsu Sayaka, Ishimori Koichiro

Abstract excerpt

HutZ from Vibrio cholerae is a dimeric enzyme that catalyzes degradation of heme. The highly conserved Arg92 residue in the HutZ family is proposed to interact with an iron-bound water molecule in the distal heme pocket. To clarify the specific role of Arg92 in the heme degradation reaction, the residue was substituted with alanine, leucine, histidine or lysine to modulate electrostatic interactions with...

Topics

Arginine
Bacterial Proteins
Heme
Ligands
Mixed Function Oxygenases
Mutation
Oxidation-Reduction
Protein Binding
Vibrio cholerae
Water

Source

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Identifiers

PMID: 31689379
DOI: 10.1016/j.abb.2019.108165

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