Article
Why is DsbA such an oxidizing disulfide catalyst?
Cell - 15 Dec 1995
Grauschopf U, Winther J R, Korber P, Zander T, Dallinger P, Bardwell J C
Abstract excerpt
DsbA, a member of the thioredoxin family of disulfide oxidoreductases, acts in catalyzing disulfide bond formation by donating its disulfide to newly translocated proteins. We have found that the two central residues within the active site Cys-30-Pro-31-His-32-Cys-33 motif are critical in determining the exceptional oxidizing power of DsbA. Mutations that change these two residues can alter the equilibrium...
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