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Article

A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.

Oncotarget - 9 May 2017

Thurm Christoph, Poltorak Mateusz P, Reimer Elisa, Brinkmann Melanie M, Leichert Lars, Schraven Burkhart, Simeoni Luca

Abstract excerpt

ζ-associated protein of 70 kDa (Zap70) is crucial for T-cell receptor (TCR) signaling. Loss of Zap70 in both humans and mice results in severe immunodeficiency. On the other hand, the expression of Zap70 in B-cell malignancies correlates with the severity of the disease. Because of its role in immune-related disorders, Zap70 has become a therapeutic target for the treatment of human diseases. It is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28415650
DOI: 10.18632/oncotarget.16486
PMCID: PMC5458169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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