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Article

Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization.

Molecular and cellular biology - 1 May 2012

Nardozza Aurelio Pio, D'Orazio Melania, Trapannone Riccardo, Corallino Salvatore, Filomeni Giuseppe, Tartaglia Marco, Battistoni Andrea, Cesareni Gianni, Castagnoli Luisa

Abstract excerpt

The SHP-2 tyrosine phosphatase plays key regulatory roles in the modulation of the cell response to growth factors and cytokines. Over the past decade, the integration of genetic, biochemical, and structural data has helped in interpreting the pathological consequences of altered SHP-2 function. Using complementary approaches, we provide evidence here that endogenous SHP-2 can dimerize through the formation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22411627
DOI: 10.1128/MCB.06674-11
PMCID: PMC3347403

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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