Article
Multiple cysteine residues are implicated in Janus kinase 2-mediated catalysis.
Biochemistry - 25 Dec 2007
Mamoon Naila M, Smith John K, Chatti Kiranam, Lee Sheeyong, Kundrapu Kanakadurga, Duhé Roy J
Abstract excerpt
The redox regulation of Janus kinase 2 (JAK2) is poorly understood, and there are contradictory reports as to whether the enzyme's activity is inhibited or stimulated by oxidizing conditions in the cell. Here we demonstrate that multiple cysteine residues within the JAK2 catalytic domain may be crucial for enzymatic activity. The enzyme is catalytically inactive when oxidized; activity can be restored via...
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