Article
Distinctive contributions of the ribosomal P-site elements m2G966, m5C967 and the C-terminal tail of the S9 protein in the fidelity of initiation of translation in Escherichia coli.
Nucleic acids research - 1 May 2013
Arora Smriti, Bhamidimarri Satya Prathyusha, Bhattacharyya Moitrayee, Govindan Ashwin, Weber Michael H W, Vishveshwara Saraswathi, Varshney Umesh
Abstract excerpt
The accuracy of pairing of the anticodon of the initiator tRNA (tRNA(fMet)) and the initiation codon of an mRNA, in the ribosomal P-site, is crucial for determining the translational reading frame. However, a direct role of any ribosomal element(s) in scrutinizing this pairing is unknown. The P-site elements, m(2)G966 (methylated by RsmD), m(5)C967 (methylated by RsmB) and the C-terminal tail of the protein S9...
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