Article
A Survey of Opsin Localization, Glycosylation, and Light/Chromophore Influence on Degeneration in 26 Rhodopsin-Associated RP Models.
Investigative ophthalmology & visual science - 1 Dec 2025
Loewen Aaron D, Tam Beatrice M, Chiu Colette N, Scharbach Ross T, Moritz Orson L
Abstract excerpt
Purpose: Mutations in rhodopsin (RHO) cause autosomal-dominant RP, which has multiple clinical subclasses, including class B1 ("sector") RP in which the asymmetric retinal degeneration (RD) suggests an environmental influence. The pathogenic mechanisms of most class B1 mutations are uncharacterized. We generated new animal models of RHO-associated RP to examine RHO expression, localization, glycosylation, and the...
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