Article
Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.
PLoS pathogens - 1 Jan 2012
Li Jun, Hakata Yoshiyuki, Takeda Eri, Liu Qingping, Iwatani Yasumasa, Kozak Christine A, Miyazawa Masaaki
Abstract excerpt
Mouse apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like editing complex 3 (mA3), an intracellular antiviral factor, has 2 allelic variations that are linked with different susceptibilities to beta- and gammaretrovirus infections among various mouse strains. In virus-resistant C57BL/6 (B6) mice, mA3 transcripts are more abundant than those in susceptible BALB/c mice both in the spleen and bone...
Topics
- Animals
- Biological Evolution
- Cell Line, Transformed
- Cytidine Deaminase
- Exons
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mutagenesis, Site-Directed
- Polymorphism, Single Nucleotide
- Protein Biosynthesis
- Protein Stability