Article
Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease.
Inflammatory bowel diseases - 1 Aug 2010
Ippoliti Andrew, Devlin Shane, Mei Ling, Yang Huiying, Papadakis Konstantinos A, Vasiliauskas Eric A, McGovern Dermot P B, Abreu Maria T, Melmed Gil, Shaye Omid, Enayati Pedram, Chen Gary, Choi Jennifer, Taylor Kent, Landers Carol J, Rotter Jerome I, Targan Stephan R
Abstract excerpt
BACKGROUND: Mutations in the nucleotide oligomerization domain-2 (NOD2) gene and positive antibodies to microbial antigens have been found to be associated with the Crohn's disease (CD) phenotype, fibrostenosis. The aim of this study was to confirm these relationships in a large cohort of CD patients and to determine the correlation between the presence of NOD2 variants and antibodies to oligomannan, CBir, outer...
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