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Article

ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.

The Journal of biological chemistry - 15 Apr 2005

Dietrich Lars E P, LaGrassa Tracy J, Rohde Jan, Cristodero Marina, Meiringer Christoph T A, Ungermann Christian

Abstract excerpt

Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE Ykt6. Here we analyzed the regulation of this reaction on purified vacuoles. We show that Vac8 acylation is restricted to a narrow time window, is independent of...

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Source

Identifiers

PMID: 15701652
DOI: 10.1074/jbc.M410582200

Genes

NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.PMID 15701652Read ↗

The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion.Semantic proximity Read ↗

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The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8.Semantic proximity Read ↗

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Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion.Semantic proximity Read ↗

Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole.Semantic proximity Read ↗

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