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Article

Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jun 2012

Salatino-Oliveira Angélica, Genro Julia P, Guimarães Ana P, Chazan Rodrigo, Zeni Cristian, Schmitz Marcelo, Polanczyk Guilherme, Roman Tatiana, Rohde Luis A, Hutz Mara H

Abstract excerpt

COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD): that is, oppositional defiant disorder (ODD) and conduct disorder (CD) often comorbid with ADHD. The aim of this study was to test the association between COMT Val(158)Met polymorphism and the presence of DBD in children with ADHD (n = 516). Homozygous...

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Share to Attention Deficit and Disruptive Behavior Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22270685
DOI: 10.1007/s00702-012-0766-2

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD.PMID 22270685Read ↗

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The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD.Semantic proximity Read ↗

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