Catechol-O-methyltransferase Val158-Met polymorphism and a response of hyperactive-impulsive symptoms to methylphenidate: A replication study from South Korea.

doi:10.1177/0269881114527654

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Article

Catechol-O-methyltransferase Val158-Met polymorphism and a response of hyperactive-impulsive symptoms to methylphenidate: A replication study from South Korea.

Journal of psychopharmacology (Oxford, England) - 1 Jul 2014

Park Subin, Kim Jae-Won, Kim Bung-Nyun, Shin Min-Sup, Yoo Hee-Jeong, Cho Soo-Churl

Abstract excerpt

We investigated the association between the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) genotype and both subjective and objective treatment responses to methylphenidate in Korean children with attention-deficit/hyperactivity disorder (ADHD). We enrolled 120 medication-naïve children with ADHD in an open-label, 8-week trial of methylphenidate. The participants were genotyped and evaluated using the...

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PMID: 24763183
DOI: 10.1177/0269881114527654

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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