Article
Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on oppositional symptoms in boys with attention-deficit/hyperactivity disorder.
Biological psychiatry - 1 Aug 2011
Salatino-Oliveira Angélica, Genro Julia P, Zeni Cristian, Polanczyk Guilherme V, Chazan Rodrigo, Guimarães Ana P, Callegari-Jacques Sidia M, Rohde Luis A, Hutz Mara H
Abstract excerpt
BACKGROUND: The catechol-O-methyltransferase enzyme plays a key role in the function of prefrontal cortex, accounting for most of the degradation of dopamine. Previous studies have documented the improvement of oppositional symptoms in attention-deficit/hyperactivity disorder (ADHD) patients with methylphenidate (MPH) treatment. However, the effect of the COMT gene in the response to MPH on oppositional symptoms...
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