Article
Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2013
Sheikh Haroon I, Kryski Katie R, Smith Heather J, Dougherty Lea R, Klein Daniel N, Bufferd Sara J, Singh Shiva M, Hayden Elizabeth P
Abstract excerpt
Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent...
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