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Article

Catechol-O-methyltransferase Val158Met polymorphism and hyperactivity symptoms in Egyptian children with autism spectrum disorder.

Research in developmental disabilities - 1 Jul 2013

Karam Rehab A, Rezk Noha A, Abdelrahman Hadeel M, Hassan Tamer H, Mohammad Doaa, Hashim Haitham M, Fattah Nelly R A Abdel

Abstract excerpt

Catechol-O-methyltransferase (COMT) plays an important role in the catabolism of brain dopamine and norepinephrine, which have been implicated in the pathogenesis of Autism spectrum disorder (ASD) as well as in other neuropsychatric disorders. We aimed to investigate the association of COMT Val158Met gene polymorphism with ASD and to examine the influence of such genotypes on hyperactivity symptoms in ASD...

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Identifiers

PMID: 23643763
DOI: 10.1016/j.ridd.2013.04.002

Genes

COMT

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