Article
Role of COMT in ADHD: a systematic meta-analysis.
Molecular neurobiology - 1 Feb 2014
Sun Hongjuan, Yuan Fangfen, Shen Xuemei, Xiong Guanglian, Wu Jing
Abstract excerpt
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable childhood-onset psychiatric disorder with significant genetic contribution. Considerable evidence has implicated involvement of dopaminergic system and the prefrontal cortex (PFC) in the pathomechanism of ADHD. The catechol-O-methyltransferase (COMT) gene is of particular interest for ADHD as its crucial role in the degradation of...
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