Article
Clearance of amyloid-β protein deposits in transgenic mice following focal cerebral ischemia.
Neuro-degenerative diseases - 1 Jan 2012
Van Nostrand W E, Davis J, Previti M L, Xu F
Abstract excerpt
BACKGROUND/AIMS: There is increased amyloid-β protein precursor (AβPP) expression and amyloid-β protein (Aβ) production in the brain shortly following cerebral ischemic stroke in rodent models. It has been postulated that this may seed amyloid deposition in the brain. On the other hand, it remains unclear how cerebral ischemia affects preexisting Aβ deposits in the brain. Here we determine the consequences of...
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