Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.

Acta neuropathologica communications - 24 Sept 2018

Nguyen Thuy-Vi V, Hayes Megan, Zbesko Jacob C, Frye Jennifer B, Congrove Nicole R, Belichenko Nadia P, McKay Brian S, Longo Frank M, Doyle Kristian P

Abstract excerpt

The goal of this study was to determine the chronic impact of stroke on the manifestation of Alzheimer's disease (AD) related pathology and behavioral impairments in mice. To accomplish this goal, we used two distinct models. First, we experimentally induced ischemic stroke in aged wildtype (wt) C57BL/6 mice to determine if stroke leads to the manifestation of AD-associated pathological β-amyloid (Aβ) and tau in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maze Learning

Share to Motor Activity

Share to Myelin Sheath

Share to Plaque, Amyloid

Share to Presenilin-1

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 30249297
DOI: 10.1186/s40478-018-0603-4
PMCID: PMC6154927

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.PMID 30249297Read ↗

Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humansSemantic proximity Read ↗

Cerebrovascular phenotypes in mouse models of Alzheimer's disease.Semantic proximity Read ↗

Molecular and anatomical roadmap of stroke pathology in immunodeficient miceSemantic proximity Read ↗

Aberrant Hippocampal Neurogenesis is A Conserved Response to Stroke in Mice: A Multi-Center Multimodel StudySemantic proximity Read ↗

Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer’s diseaseSemantic proximity Read ↗

Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer’s Disease: Implications from a Transgenic Mouse Model of the DiseaseSemantic proximity Read ↗

Postischemic dementia with Alzheimer phenotype: selectively vulnerable versus resistant areas of the brain and neurodegeneration versus β-amyloid peptide.Semantic proximity Read ↗

Age-specific transcriptional response to stroke.Semantic proximity Read ↗

Clearance of amyloid-β protein deposits in transgenic mice following focal cerebral ischemia.Semantic proximity Read ↗

The role of apolipoprotein E in Alzheimer’s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal modelsSemantic proximity Read ↗

A molecular brain atlas reveals cellular shifts during the repair phase of strokeSemantic proximity Read ↗

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.