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Article

Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 May 2008

Xu Feng, Vitek Michael P, Colton Carol A, Previti Mary Lou, Gharkholonarehe Nastaran, Davis Judianne, Van Nostrand William E

Abstract excerpt

Human apolipoprotein (ApoE) genotype influences the development of Alzheimer's disease and cerebral amyloid angiopathy (CAA). Specific mutations within the amyloid-beta protein (Abeta) peptide have been identified that cause familial forms of CAA. However, the effect of APOE genotype on accumulation of CAA mutant Abeta in brain is not well understood. In the present study, we determined how human ApoE3 or ApoE4...

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Identifiers

PMID: 18480287
DOI: 10.1523/JNEUROSCI.1042-08.2008
PMCID: PMC2657728

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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