Article
Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia.
Neuroreport - 13 Dec 1993
Chan P H, Kamii H, Yang G, Gafni J, Epstein C J, Carlson E, Reola L
Abstract excerpt
Using a mouse model with intraluminal blockade of the middle cerebral artery (MCA) which produced both cortical and striatal infarction, the effect that superoxide radicals have on cerebral infarction, local cerebral blood flow, and neurological deficits after 24 h of permanent focal cerebral ischemia in transgenic mice (Tg) overexpressing human CuZn-superoxide dismutase (SOD-1) was examined. There were no...
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