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Article

Characterization of the C. elegans erlin homologue.

BMC cell biology - 23 Jan 2012

Hoegg Maja B, Robbins Stephen M, McGhee James D

Abstract excerpt

BACKGROUND: Erlins are highly conserved proteins associated with lipid rafts within the endoplasmic reticulum (ER). Biochemical studies in mammalian cell lines have shown that erlins are required for ER associated protein degradation (ERAD) of activated inositol-1,4,5-trisphosphate receptors (IP3Rs), implying that erlin proteins might negatively regulate IP3R signalling. In humans, loss of erlin function appears...

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PMID: 22269071
DOI: 10.1186/1471-2121-13-2
PMCID: PMC3292932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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