Article
The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2007
Matsubara Yosuke, Kawasaki Ichiro, Urushiyama Seiichi, Yasuda Tomoharu, Shirakata Masaki, Iino Yuichi, Shibuya Hiroshi, Yamanashi Yuji
Abstract excerpt
The Ras-MAP kinase pathway regulates varieties of fundamental cellular events. In Caenorhabditis elegans, this pathway is required for oocyte development; however, the nature of its up-stream regulators has remained elusive. Here, we identified a C. elegans gene, rog-1, which encodes the only protein having the IRS-type phosphotyrosine-binding (PTB) domain in the worms. ROG-1 has no obvious domain structure aside...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.