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Article

Loss of the seipin gene perturbs eggshell formation in Caenorhabditiselegans.

Development (Cambridge, England) - 16 Oct 2020

Bai Xiaofei, Huang Leng-Jie, Chen Sheng-Wen, Nebenfuehr Benjamin, Wysolmerski Brian, Wu Jui-Ching, Olson Sara K, Golden Andy, Wang Chao-Wen

Abstract excerpt

Seipin, an evolutionary conserved protein, plays pivotal roles during lipid droplet (LD) biogenesis and is associated with various human diseases with unclear mechanisms. Here, we analyzed Caenorhabditis elegans mutants deleted of the sole SEIPIN gene, seip-1 Homozygous seip-1 mutants displayed penetrant embryonic lethality, which is caused by the disruption of the lipid-rich permeability barrier, the innermost...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32820022
DOI: 10.1242/dev.192997
PMCID: PMC7578359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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