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Article

Intratumoral Heterogeneity in the Self‐Renewal and Tumorigenic Differentiation of Ovarian Cancer

20 Jan 2012

Abstract excerpt

Resistance to anticancer therapy has been attributed to interindividual differences in gene expression pathways among tumors, and to the existence within tumors of cancer stem cells with self-renewal capacity. In previous studies, we have demonstrated that the human embryonic stem cell (hESC)-derived cellular microenvironment in immunocompromised mice enables functional distinction of heterogeneous tumor cells,...

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PMID: 22267284
DOI: 10.1002/stem.1029

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