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Article

Understanding cancer stem cell heterogeneity and plasticity.

Cell research - 1 Mar 2012

Tang Dean G

Abstract excerpt

Heterogeneity is an omnipresent feature of mammalian cells in vitro and in vivo. It has been recently realized that even mouse and human embryonic stem cells under the best culture conditions are heterogeneous containing pluripotent as well as partially committed cells. Somatic stem cells in adult organs are also heterogeneous, containing many subpopulations of self-renewing cells with distinct regenerative...

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Identifiers

PMID: 22357481
DOI: 10.1038/cr.2012.13
PMCID: PMC3292302

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