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Article

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer.

Cell stem cell - 3 Sept 2015

Brooks Michael D, Burness Monika L, Wicha Max S

Abstract excerpt

Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex...

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Identifiers

PMID: 26340526
DOI: 10.1016/j.stem.2015.08.014
PMCID: PMC4560840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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