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Article

Increased medial orbitofrontal and amygdala activation: evidence for a systems-level endophenotype of bipolar I disorder.

The American journal of psychiatry - 1 Mar 2012

Linke Julia, King Andrea Victoria, Rietschel Marcella, Strohmaier Jana, Hennerici Michael, Gass Achim, Meyer-Lindenberg Andreas, Wessa Michèle

Abstract excerpt

OBJECTIVE: Bipolar I disorder is highly heritable, but endophenotypes of the disorder mediating genetic risk are only beginning to be defined. The authors investigate state- and trait-related neural mechanisms related to motivation in euthymic bipolar patients and unaffected first-degree relatives of bipolar patients to define the status of motivational processing as a neural systems-level endophenotype. METHOD:...

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Source

Identifiers

PMID: 22267184
DOI: 10.1176/appi.ajp.2011.11050711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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