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Article

Network dysfunction of emotional and cognitive processes in those at genetic risk of bipolar disorder.

Brain : a journal of neurology - 1 Nov 2015

Breakspear Michael, Roberts Gloria, Green Melissa J, Nguyen Vinh T, Frankland Andrew, Levy Florence, Lenroot Rhoshel, Mitchell Philip B

Abstract excerpt

The emotional and cognitive vulnerabilities that precede the development of bipolar disorder are poorly understood. The inferior frontal gyrus-a key cortical hub for the integration of cognitive and emotional processes-exhibits both structural and functional changes in bipolar disorder, and is also functionally impaired in unaffected first-degree relatives, showing diminished engagement during inhibition of...

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PMID: 26373604
DOI: 10.1093/brain/awv261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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