Article
Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.
Molecular biology and evolution - 1 Aug 2013
Huerta-Sánchez Emilia, Degiorgio Michael, Pagani Luca, Tarekegn Ayele, Ekong Rosemary, Antao Tiago, Cardona Alexia, Montgomery Hugh E, Cavalleri Gianpiero L, Robbins Peter A, Weale Michael E, Bradman Neil, Bekele Endashaw, Kivisild Toomas, Tyler-Smith Chris, Nielsen Rasmus
Abstract excerpt
The Tibetan and Andean Plateaus and Ethiopian highlands are the largest regions to have long-term high-altitude residents. Such populations are exposed to lower barometric pressures and hence atmospheric partial pressures of oxygen. Such "hypobaric hypoxia" may limit physical functional capacity, reproductive health, and even survival. As such, selection of genetic variants advantageous to hypoxic adaptation is...
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