Article
Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes.
Genome biology - 20 Feb 2014
Udpa Nitin, Ronen Roy, Zhou Dan, Liang Junbin, Stobdan Tsering, Appenzeller Otto, Yin Ye, Du Yuanping, Guo Lixia, Cao Rui, Wang Yu, Jin Xin, Huang Chen, Jia Wenlong, Cao Dandan, Guo Guangwu, Claydon Victoria E, Hainsworth Roger, Gamboa Jorge L, Zibenigus Mehila, Zenebe Guta, Xue Jin, Liu Siqi, Frazer Kelly A, Li Yingrui, Bafna Vineet, Haddad Gabriel G
Abstract excerpt
BACKGROUND: Although it has long been proposed that genetic factors contribute to adaptation to high altitude, such factors remain largely unverified. Recent advances in high-throughput sequencing have made it feasible to analyze genome-wide patterns of genetic variation in human populations. Since traditionally such studies surveyed only a small fraction of the genome, interpretation of the results was limited....
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