Article
Cutting edge: a variant of the IL-23R gene associated with inflammatory bowel disease induces loss of microRNA regulation and enhanced protein production.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2012
Zwiers Antonie, Kraal Laurens, van de Pouw Kraan Tineke C T M, Wurdinger Thomas, Bouma Gerd, Kraal Georg
Abstract excerpt
IL-23R gene variants have been identified as risk factors for two major inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, but how they contribute to disease is poorly understood. In this study, we show that the rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of...
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