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A functional microRNA binding site variant in IL-23R gene in systemic lupus erythematosus and rheumatoid arthritis: is there any correlation?

Molecular biology reports - 1 Dec 2022

Alesaeidi Samira, Dizghandi Saeed Esmaeili, Siri Goli, Mosallaei Meysam, Kenarangi Taiebe, Ghorashi Tahereh, Soosanabadi Mohsen

Abstract excerpt

BACKGROUND: IL-23 receptor (IL-23R) dysregulation has been shown to have critical roles in pathogenesis of different autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) via suppression of regulatory T cells (Tregs) as well as differentiation, expansion, and survival of T helper 17 (Th17) cells, followed by upregulation of interleukin 17 (IL-17). Here, we assessed the...

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PMID: 36214949
DOI: 10.1007/s11033-022-07922-z

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