Article
Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease.
Gut - 1 Nov 2011
Kim Seung Won, Kim Eun Soo, Moon Chang Mo, Park Jae Jun, Kim Tae Il, Kim Won Ho, Cheon Jae Hee
Abstract excerpt
BACKGROUND AND AIMS: To identify the associations of genetic and epigenetic variations in IL-23R and IL-17A with inflammatory bowel diseases (IBD). METHODS: The promoter and exon regions of IL-23R and IL-17A were analysed in 727 subjects (201 Crohn's disease, 268 ulcerative colitis and 258 healthy controls) using DNA sequencing and denaturing high performance liquid chromatography. Transcription factor binding...
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