Article
Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise.
Pharmacogenetics and genomics - 1 Apr 2012
Ghimire Laxmi V, Kohli Utkarsh, Li Chun, Sofowora Gbenga G, Muszkat Mordechai, Friedman Eitan A, Solus Joseph F, Wood Alastair J J, Stein C Michael, Kurnik Daniel
Abstract excerpt
OBJECTIVE: To examine the hypothesis that genetic variation in enzymes and transporters associated with synthesis, storage, release, and metabolism of catecholamines contributes to the interindividual variability in plasma catecholamine concentrations at rest and after exercise. METHODS: We measured plasma norepinephrine (NE) and epinephrine concentrations at rest and after a standardized exercise protocol in 165...
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