Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.

European journal of clinical pharmacology - 1 Mar 2018

Vizeli Patrick, Meyer Zu Schwabedissen Henriette E, Liechti Matthias E

Abstract excerpt

PURPOSE: Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α1-adrenergic receptors. Genetic variants, such as single-nucleotide polymorphisms (SNPs), of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Cardiovascular Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Over Studies

Share to Double-Blind Method

Share to Heart Rate

Share to Norepinephrine Plasma Membrane Transport Proteins

Share to Psychotropic Drugs

Share to Switzerland

Source

Open in PubMed Open full text

Identifiers

PMID: 29198060
DOI: 10.1007/s00228-017-2392-2
PMCID: PMC5808057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.PMID 29198060Read ↗

Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”): The Influence of Gender and Genetics (CYP2D6, COMT, 5-HTT)Semantic proximity Read ↗

Factors Influencing the Cardiovascular Response to Subanesthetic Ketamine: A Randomized, Placebo-Controlled Trial.Semantic proximity Read ↗

Norepinephrine transporter gene variation modulates acute response to D-amphetamine.Semantic proximity Read ↗

Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome.Semantic proximity Read ↗

Cardiovascular Effects and Safety of Lisdexamfetamine in Attention-Deficit/Hyperactivity Disorder and Healthy Volunteers: A Systematic Review.Semantic proximity Read ↗

Norepinephrine transporter -3081(A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS-methylphenidate treatment.Semantic proximity Read ↗

Further evidence of association between amphetamine response and SLC6A2 gene variants.Semantic proximity Read ↗

Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.Semantic proximity Read ↗

Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise.Semantic proximity Read ↗

Genetic polymorphisms and the adequacy of brain stimulation: state of the art.Semantic proximity Read ↗

Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers.Semantic proximity Read ↗

Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.