Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

Molecular and cellular biology - 1 Jul 1992

Ucker D S, Obermiller P S, Eckhart W, Apgar J R, Berger N A, Meyers J

Abstract excerpt

We examined virally transformed murine fibroblast clones as targets for cytotoxic T lymphocyte (CTL)-triggered lysis and genome digestion. Strikingly, while all clones were essentially equivalent in the ability to be lysed, one clone, SV3T3-B2.1, failed to exhibit genome digestion associated with CTL attack. Other aspects of the physiological cell death process, including loss of adhesion and nuclear envelope...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Genetic Variation

Share to T-Lymphocytes, Cytotoxic

Share to Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1620115
DOI: 10.1128/mcb.12.7.3060-3069.1992
PMCID: PMC364520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.PMID 1620115Read ↗

Cell-autonomous requirement for DNaseII in nonapoptotic cell deathSemantic proximity Read ↗

Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanisms.Semantic proximity Read ↗

Epstein-Barr virus induces fragmentation of chromosomal DNA during lytic infectionSemantic proximity Read ↗

Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.Semantic proximity Read ↗

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.Semantic proximity Read ↗

Three distinct cell phenotypes of induced-TNF cytotoxicity and their relationship to apoptosis.Semantic proximity Read ↗

A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli.Semantic proximity Read ↗

Genetic defects affecting lymphocyte cytotoxicity.Semantic proximity Read ↗

Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 LossSemantic proximity Read ↗

GTP-binding-defective forms of tissue transglutaminase trigger cell death.Semantic proximity Read ↗

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.Semantic proximity Read ↗

Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.