Article
Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2012
Stevens Kristen N, Kelemen Linda E, Wang Xianshu, Fridley Brooke L, Vierkant Robert A, Fredericksen Zachary, Armasu Sebastian M, Tsai Ya-Yu, Berchuck Andrew, Narod Steven A, Phelan Catherine M, Sutphen Rebecca, Birrer Michael J, Schildkraut Joellen M, Sellers Thomas A, Goode Ellen L, Couch Fergus J
Abstract excerpt
BACKGROUND: Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined. METHODS: We measured associations between 397 single nucleotide polymorphisms (SNPs) from 67 mitotic kinases and invasive epithelial ovarian cancer risk in two...
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