Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.

Nature chemical biology - 19 Feb 2012

Grzegorzewicz Anna E, Pham Ha, Gundi Vijay A K B, Scherman Michael S, North Elton J, Hess Tamara, Jones Victoria, Gruppo Veronica, Born Sarah E M, Korduláková Jana, Chavadi Sivagami Sundaram, Morisseau Christophe, Lenaerts Anne J, Lee Richard E, McNeil Michael R, Jackson Mary

Abstract excerpt

New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis are urgently needed. We report on the identification of an adamantyl urea compound that shows potent bactericidal activity against M. tuberculosis and a unique mode of action, namely the abolition of the translocation of mycolic acids from the cytoplasm, where they are synthesized to the periplasmic side of the plasma membrane and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Mycobacterium tuberculosis

Share to Mycolic Acids

Share to Phenylurea Compounds

Share to Small Molecule Libraries

Share to Trehalose

Source

Open in PubMed Open full text

Identifiers

PMID: 22344175
DOI: 10.1038/nchembio.794
PMCID: PMC3307863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.PMID 22344175Read ↗

Mycobacterial Membrane Protein Large 3 (MmpL3) Inhibitors: A Promising Approach to Combat TuberculosisSemantic proximity Read ↗

Thienopyrimidine amide analogs target MmpL3 in Mycobacterium tuberculosis.Semantic proximity Read ↗

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.Semantic proximity Read ↗

Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.Semantic proximity Read ↗

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial InfectionsSemantic proximity Read ↗

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus InfectionsSemantic proximity Read ↗

Cell Surface Biosynthesis and Remodeling Pathways in Mycobacteria Reveal New Drug TargetsSemantic proximity Read ↗

HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid TransporterSemantic proximity Read ↗

MmpL3 is the flippase for mycolic acids in mycobacteriaSemantic proximity Read ↗

Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid TransportSemantic proximity Read ↗

A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3Semantic proximity Read ↗

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force DisruptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.