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Article

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.

Scientific reports - 27 Feb 2017

Degiacomi Giulia, Benjak Andrej, Madacki Jan, Boldrin Francesca, Provvedi Roberta, Palù Giorgio, Kordulakova Jana, Cole Stewart T, Manganelli Riccardo

Abstract excerpt

MmpL3 is an inner membrane transporter of Mycobacterium tuberculosis responsible for the export of trehalose momomycolate, a precursor of the mycobacterial outer membrane component trehalose dimycolate (TDM), as well as mycolic acids bound to arabinogalactan. MmpL3 represents an emerging target for tuberculosis therapy. In this paper, we describe the construction and characterization of an mmpL3 knockdown strain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28240248
DOI: 10.1038/srep43495
PMCID: PMC5327466

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