Article
Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.
The Journal of biological chemistry - 4 Jun 2010
Ojha Anil K, Trivelli Xavier, Guerardel Yann, Kremer Laurent, Hatfull Graham F
Abstract excerpt
Mycobacterial species, like other microbes, spontaneously form multicellular drug-tolerant biofilms when grown in vitro in detergent-free liquid media. The structure of Mycobacterium tuberculosis biofilms is formed through genetically programmed pathways and is built upon a large abundance of novel extracellular free mycolic acids (FM), although the mechanism of FM synthesis remained unclear. Here we show that...
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