Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients.

BMC cancer - 17 Jan 2012

Lang Alois H, Geller-Rhomberg Simone, Winder Thomas, Stark Nicole, Gasser Klaus, Hartmann Bernd, Kohler Bertram, Grizelj Ina, Drexel Heinz, Muendlein Axel

Abstract excerpt

BACKGROUND: The newly discovered metastasis-associated in colon cancer-1 (MACC1) gene is a key regulator of the HGF/MET pathway. Deregulation of HGF/MET signaling is reported as a prognostic marker for tumorigenesis, early stage invasion, and metastasis. High expression levels of MACC1 have been associated with colon cancer metastasis and reduced survival. Potential links between the genetic diversity of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Austria
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Gene Expression Regulation, Neoplastic

Share to Kaplan-Meier Estimate

Share to Proportional Hazards Models

Share to Survival Analysis

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 22251819
DOI: 10.1186/1471-2407-12-20
PMCID: PMC3282635

Genes

MACC1
HGF
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients.PMID 22251819Read ↗

SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer.Semantic proximity Read ↗

Significant survival impact of MACC1 polymorphisms in HER2 positive breast cancer patients.Semantic proximity Read ↗

High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients.Semantic proximity Read ↗

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.Semantic proximity Read ↗

Genetic Variation in Metastasis-Associated in Colon Cancer-1 and the Risk of Breast Cancer Among the Chinese Han Population: A STROBE-Compliant Observational Study.Semantic proximity Read ↗

Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancerSemantic proximity Read ↗

Single nucleotide polymorphisms in the metastasis-associated in colon cancer-1 gene predict the recurrence of hepatocellular carcinoma after transplantation.Semantic proximity Read ↗

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic CorrelationsSemantic proximity Read ↗

A retrospective observational study of the relationship between single nucleotide polymorphisms associated with the risk of developing colorectal cancer and survival.Semantic proximity Read ↗

Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival.Semantic proximity Read ↗

Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.Semantic proximity Read ↗

A Cohort Study of STMN1 Expression in Colorectal Cancer: Body Mass Index and PrognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.