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Article

Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancer

6 Jun 2013

Abstract excerpt

MACC1, Metastasis associated in colon cancer 1, is a newly identified prognostic biomarker for colorectal cancer metastasis and patient survival, when determined in the primary tumor or patient blood. MACC1 induces cell motility and proliferation in cell culture and metastasis in mouse models. MACC1 acts as a transcriptional regulator of the receptor tyrosine kinase gene Met via binding to its promoter. However,...

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Identifiers

PMID: 23800415
DOI: 10.1016/j.molonc.2013.05.003

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